Gaku Fukuhara
Osaka University, Japan
Title: Pharmaceutical Oligosaccharide Sensing by a Chemical Approach
Biography
Biography: Gaku Fukuhara
Abstract
Selective sensing of oligosaccharides in aqueous media is a challenge in current chemistry due to their heavy hydration and stereochemical diversity. Thus, the development of selective saccharide sensor that functions in aqueous media is of particular significance and benefit not only from the scientific but also from the application point of view.
In this study, we synthesized reporter-modified curdlan (DABz-Cur) as a saccharide chemosensor, and investigated its abilities for sensing a variety of oligosaccharides by using circular dichroism spectroscopy to find a specifically high sensitivity for one of tetrasaccharides, i.e. acarbose shown in Figure 1a. Acarbose is a drug to treat type-2 diabetes mellitus and obesity by inhibiting α-glucosidase that releases glucose from higher carbohydrates, and therefore its detection is of particular significance from the diagnostic viewpoint. The saccharide sensing results of further interesting approach by an in situ hybrid sensor with Cur and PyPT in Figure 1b and their detailed supramolecular complexation will be discussed.