Sabah H. Akrawi
King Faisal University, Saudi Arabia
Title: Potentiation of gentamicin induced nephrotoxicity by molsidomine in rats
Biography
Biography: Sabah H. Akrawi
Abstract
Reactive oxygen metabolites have been implicated in gentamicin induced nephrotoxicity. This study tests whether or not nephrotoxicity of gentamicin is associated with cellular activation or lipid peroxidation and the use of vasodilator, molsidomine, plays a role in the renal lesion. Male Wister 200-300 g rats were distributed randomly into five groups, Saline treated group, Molsidomine treated group, Gentamicin treated group, Molsidomine + Gentamicin treated group, and Gentamicin + Ethanol treated group. The results showed that gentamicin induced nephrotoxicity was associated with a significant activation of cellular lipid peroxidation manifested by high serum and cortical tissue malondialdehyde, and the use of molsidomine aggravates this process. These data indicate that vasodilators and in particular those with nitric oxide (NO) dinating property may be extremely harmful when used with gentamicin.