Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 4th International Pharma & Clinical Pharmacy Congress Las Vegas, Nevada, USA.

Day 1 :

Keynote Forum

Roseane Maria Maia Santos

South University School of Pharmacy, USA

Keynote: The Search for genomic markers for coffee consumption

Time : 09:45-10:25

OMICS International Clinical Pharmacy 2016 International Conference Keynote Speaker Roseane Maria Maia Santos photo
Biography:

Santos has completed his PhD from SUNY at Buffalo and is an Associate Professor at Department of Pharmaceutical Sciences at School of Pharmacy. She has a company devoted to research and consultancy, Dr. Coffee in Savannah as well as a laboratory devoted to research on Coffee and health benefits. She has published many papers, participated as peer reviewer for various journals and has written chapters and textbooks in Portuguese, English and Korean.

Abstract:

The turnaround of the millennium brought us lots of expectation in terms of world market globalization economy, planet environment preservation and energy resources to mention a few. However, one of the most important discoveries in the science field was the unveiling of the human genome. Since then, most of the attention has turned to understanding the function of many genes and genomic fragments and their relationship with human pathophysiology. Much has been accomplished so far, such as BRCA1 and BRCA2 markers for breast cancer; HOXB13 gene for prostate cancer; APOE ε4 for Alzheimer’s disease and many others that lead to the possibility of genetic testing to predict the risk of developing the disease, if the mutant variant gene is expressed in the individual genome.

Coffee is the mostly widely consumed beverage worldwide with known health benefits. The genomic approach to search for specific regions in the human DNA that are highly expressed within the coffee consumers is also a recent phenomenon. Genome-wide association studies (GWAS) have identified a number of regions of interest associated with coffee consumption. A consortium actually was created with the participation of researchers from all over the world, in an effort to accelerate these findings. The purpose is to understand the relationship between parts of the human DNA and the increased or decreased coffee use and its correlation with the prevention of a series of diseases as type-2 diabetes, cancers and neurodegenerative diseases that account for the majority of the chronic disorders that afflict our post-millennium population.

Keynote Forum

Monika I Konaklieva

American University, USA

Keynote: Molecular targets of b-lactams-beyond the usual suspects

Time : 10:25-11:05

OMICS International Clinical Pharmacy 2016 International Conference Keynote Speaker Monika I Konaklieva photo
Biography:

Monika Konaklieva completed her PhD in Chemistry - Organic Synthesis from SUNY Buffalo -1997, and became a visiting professor in Medicinal Chemistry at Midwestern University, Chicago, Illinois (1997-1999). She is currently an Associate Professor at American University. She has published more than 40 papers in reputed journals and has been serving as an editorial board member of several chemistry journals publishing in the areas of organic and medicinal chemistry.

Abstract:

b-Lactams have historically been viewed as a class of antimicrobials. However, this paradigm is shifting towards a focus on their ability to function as inhibitors of bacterial enzymes, particularly those involved in broad-spectrum b-lactam resistance, i.e., extended spectrum b-lactamases (ESBL). This shift in focus is the result of the recognition of the b-lactam’s ability to acylate enzymes, the majority of which have serine as nucleophile in the active site. In addition to being inhibitors of bacterial enzymes, b-lactams also inhibit viral and mammalian serine enzymes demonstrating inter-kingdom activity. The focus of this presentation is on the evaluation of the potential of b-lactam antibiotics as inhibitors of the serine enzymes of both prokaryotic and eukaryotic origin, with specific focus on the structure-function relationship of b-lactams as antimicrobial and antineoplastic agents.