Biography
ROSEANE SANTOS, graduated at Federal University of Rio de Janeiro, Rio de Janeiro, Brazil, as Pharmacist and as Biochemical-Pharmacist, a 5-year program. Before coming to United States, she worked as Hospital Pharmacist at the Federal University of Rio de Janeiro where she had the opportunity to be involved with different aspects of clinical research and drug monitoring. Her passage by the food and drug regulatory agency of Brazil, Division of Medicines (DIMED) and as consultant for Pharmaceutical Industry strengthened her skills on regulatory affairs. She also obtained her Master Degree in Hospital Pharmacy and accepted the position as Assistant Professor of Pharmacology at private and federal universities. In 1999, she was awarded a 4-year scholarship from Brazilian Government to study abroad and came with her family to USA for PhD. Program at State University of New York at Buffalo, from where she graduated on November of 2004. Her thesis involved the knowledge of basic molecular biology techniques as cloning, immunoassays, and state-of-the-art technology such as micro-arrays, gene sequencing and real-time PCR, looking to the most different aspects of the gene expression of interferon-beta induced genes, whether playing a role in therapeutic response or as disease biomarkers. After graduation she was appointed as Assistant Professor at Pharmaceutical Sciences Department of Nova Southeastern University College of Pharmacy, Fort Lauderdale, FL. At the present, she is Assistant Professor at South University School of Pharmacy, teaching in the area of main expertise – pharmacology. Dr. Santos research laboratory is focused in the area of Coffee and Health and her major interest is on recently discovered bioactive compounds present in coffee known as chlorogenic acids and lactones and their effects on human health. Her research focus is into the characterization of a biomarker for coffee intake to provide the necessary bridge between clinical studies (epidemiologic) and basic science (molecular biology). It will make possible to correlate coffee consumption biomarker levels of specific target study population, as to potential health effects. She also works in the development of healthy byproducts from coffee, such as functional and fortified coffee and serves as consultant for coffee industry.
Research Interest
Major interest is on recently discovered bioactive compounds present in coffee known as chlorogenic acids and lactones and their effects on human health. Her research focus is into the characterization of a biomarker for coffee intake to provide the necessary bridge between clinical studies (epidemiologic) and basic science (molecular biology)
Biography
Roger Jelliffe MD, FCP, FAAPS, developed the first computer software for individualizing drug dosage regimens in 1967. He was the first to relate renal drug elimination to creatinine clearance. He developed the first method for estimating creatinine clearance when serum creatinine is changing. He founded the USC Laboratory of Applied Pharmacokinetics in 1973, and the USC*PACK and more recent MM-USCPACK clinical software for individualizing drug dosage regimens most precisely. His laboratory developed the Resource for Population Modeling at the San Diego Supercomputer Center, the nonparametric adaptive grid (NPAG) population modeling approach, and Multiple Model (MM) design of maximally precise dosage regimens. This is now the Bestdose clinical and Pmetrics research software. We have developed three new methods of Bayesian analysis for individual patients. This adds great capability and safety in managing unusual patients. He is author or co-author of 132 peer reviewed publications, has mentored over 100 visiting scientific scholars, 1 sabbatical scholar, 2 Master’s Students, 3 Ph.D candidates, and 3 mini-sabbaticals.
Research Interest
Dr. Jelliffe’s interest is now in nonlinear PK/PD population modeling of multiple interacting drug systems, optimally coordinated combination MM dosage regimens for patients, and in methods using the dose itself as an active partner to learn about the patient optimally while having to treat him/her at the same time.
Biography
Dr. Noreddin received his Ph.D. in pharmaceutical Sciences from the University of the Pacific, California and received research training as a visiting scholar at the Department of Medicine, Stanford University. He had postdoctoral fellowship (Pharmacokinetics and Pharmacodynamics of Antimicrobials), Department of Medical Microbiology, University of Manitoba followed by an American College of Clinical Pharmacy postdoctoral fellowship (Infectious Diseases). Dr. Noreddin’s research interest includes Pharmacoklinetic/Pharmacodynamic modeling of anti-infective and anti-cancer therapy, clinical simulation and Monte Carlo analysis and bacterial resistance in biofilm studies. Dr. Noreddin has outstanding records of scientific and academic accomplishments with multiple research funding, numerous publications in highly prestigious journals and various presentations in both national and international conferences. He served as a scientific reviewer for the NIH as well as other national and international research institutions.
Research Interest
1. Pharmacokinetic/Pharmacodynamic modeling of anti-infective and anti-cancer therapy 2. Clinical simulation and Monte Carlo analysis 3. Bacterial resistance in biofilm studies 4. Cancer epigenetic studies