Day 3 :
- Track 12: Biomedical Sciences
Session Introduction
Alexander E. Berezin
Zaporozhye State Medical University , Zaporozhye Ukraine
Title: Apoptotic-derived micro particles to endothelial-derived progenitor cells ratio as a novel biomarker in advanced heart failure patients
Time : 15:10-15:30
Biography:
Alexander E. Berezin received the MD degree from State Medical University, Zaporozhye, Ukraine, in 1992 (Number of License is 827456 / 6637 dated 25 JUN 1992). PhD degree in field of Heart Failure was earned in State Medical University, Zaporozhye, Ukraine in 1994. The primary qualification is internal medicine; the secondary qualifications are cardiology, rheumatology, and ultrasound exam. He is currently Professor of Medicine, Consultant of Cardiology Unit of Internal Medicine Department at State Medical University, Zaporozhye, Ukraine
Abstract:
Background: Acutely decompensated chronic heart failure (ADHF) is considered a life-threatening event. Despite contemporary treatment strategies of ADHF, frequent recurrent hospitalizations due to other cardiovascular reasons after discharge of patients from the hospital are occurred. The objective of the study was to examine prognostic value of circulating endothelial-derived apoptotic microparticles (EMPs) to endothelial origin mononuclear progenitor cells (MPCs) ratio for post-discharged patients with clinical stabilization after ischemic ADHF. Methods: We have been consecutively enrolled 136 patients (62 male) with CAD admitted with a primary diagnosis of ADHF. All the patients have given their written informed consent for participation in the study. At baseline all enrolled patients were hemodynamically stable and they had NYHA III/IV classes of ischemic CHF. Observation period started at discharge from the hospital and was up to 3 years. Flowcytometry analysis for quantifying the number of EMPs and angiogenic MPCs was used. Results: Calculated EMPs to MPCs ratios in survived and died patient cohort were 8.4 (95% CI = 7.6 – 9.2) and 78.9 (95% CI = 53.0 – 116.6) respectively (P=0.001). MPCs, EMPs, NYHA class, NT-proBNP and increased NT-proBNP > 30% within 24-48 hours of admission period remained statistically significant for all-cause mortality, CHF-related death, and CHF-related rehospitalisation, whereas LVEF and hs-CRP for all variables did not. We found that the addition of EPMs to MPCs ratio to the ABC model (NT-pro-BNP, increased NT-pro-BNP > 30%) improved the relative IDI by 19.6% for all-cause mortality, by 21.7% for CHF-related death, and by 19.5% for CHF-related rehospitalisation. Conclusion: We demonstrated that EMPs to MPCs ratio is considered more tremendous indicator of an imbalance between angiogenic and apoptotic responses with possible relation to cardiovascular outcomes in post-discharged patients with clinical stabilization after ischemic ADHF.
Kjell E Bjørnes
Center for Epidemiology and Research Methodology, University of Life Sciences Oslo, Norway
Title: The effect of Osteopathic Manipulation Therapy (OMT) in patients suffering from Gastroesophageal Reflux Disease (GERD)
Time : 14:30-14:50
Biography:
Kjell Erling Bjørnæs has completed his Master of Science in the field of Osteopathy at The University of Greenwich, UK and followed a PhD program at Center for Epidemiology and Research Methodology, University of Life Sciences Oslo, Norway He is international lecturer in Osteopathy, and researcher at Nordic Osteopathic Research Institute. The field of research is: Gastro Esophageal Reflux Disease (GERD), totally 4 studies. He is the manager at Osteopathic Clinic – Norway.
Abstract:
Aim: To compare the effect of Osteopathic Manipulation Therapy (OMT) on Gastroesophageal reflux disease (GERD) against placebo. Material: The material consists of 58 patients suffering from GERD symptoms of 10.7 years. Twenty-six males and 18 females were allocated to OMT and eight males and six females to placebo. Methods: A randomized, double observer blinded multicenter trial with stratified parallel group design was performed. Patients were allocated (3:1) to OMT or placebo by block randomization. OMT includes traction of cardia, mobilization of diaphragm and thoracic spine and posture correction once per week. The controls treated with non-active laser pen on the epigastric area. The degree and duration of GERD symptoms, provocation factors and use of anti-reflux medication was recorded by the patients. Results: All the GERD symptoms was significantly reduced (p<0.01) one week after the last treatment in the OMT group compared to none among the controls. The reductions were significantly in favor of OMT (p< 0.01). “Acid taste in mouth” and “Heart burn “explains 81% of the variation in reduced sum degree of symptoms. The median time of pain release was reduced from 1.5 to 0.5 hours in the OMT, but unchanged in the control group (p<0.01). Four patients stopped using proton pump inhibitors, one stopped the H2 treatment and four the antacid medication in OMT. The use of anti-reflux medication was unchanged in the control group. Conclusion: OMT have a significant effect on the GERD symptoms and might be an alternative in treatment of reflux esophagitis.
Julia A. Greenawalt
Indiana University of Pennsylvania,USA USA
Title: Meaningful Use, Documentation of Nursing Care, and Lessons Learned When a System Goes Off-Line
Biography:
Julia Greenawalt is working as a Asst. Professor at Indiana University of Pennsylvania. She completed her education in University of Pittsburgh. Her work experience on Clinical Research, Public Health
Abstract:
Teaching documentation skills and concepts to the emerging professional is a new challenge for nurse educators as the infusion of meaningful use is implemented within nursing's affiliating agencies. Discipline mandates and accreditation requirements expect the emerging professional to be current in technology and communication as one prepares to care for patients in contemporary times. This presentation will share how meaningful use has been incorporated into one obstetrical course in a baccalaureate nursing program. This is necessary for other disciplines to understand how and where meaningful use impacts their operations. In addition, we will discuss some of the current challenges as we go forward pulling from real life experiences of one nurse faculty member’s exposure to the infusion of meaningful use into course and practicum, events when meaningful use goes inactive and operations remain ongoing, and the actions taken to mitigate future safety and sentinel events. This experience illuminates the need for inter-professional on-going collaborative efforts to enhance patient safety from an informatics perspective. However, the best method of instruction for teaching learning to undergraduate nursing students as relates to electronic documentation remains unclear at this time. Current inquiry and future research into evidence-based practice are needed as preparation gears toward workforce ready graduates who will be skilled and adept at documentation using current technologies. Teaching skills for information systems, particularly the electronic health record, requires identification of challenges and obstacles, which can be surmounted if academe and corporate culture work in tandem.
HUMPHER FARIA DE SOUZA
Pythagoras of Ipatinga, Minas Gerais, Brazil
Title: Metabolic syndrome in adults: a systematic review directed to professional pharmacist.
Biography:
Humpher Faria de Souza has 31 years old. He is student and is completing the sixth period of the Pharmacy Course at the Faculty Pythagoras of Ipatinga, Minas Gerais, Brazil. He intended as a researcher and do master's degree in Clinical Pharmacy.
Abstract:
Metabolic syndrome (MS) results from a number of risk factors for cardiovascular disease, and the main, central obesity, hypertension and abnormalities in glucose and lipid metabolism. As obesity in the world has taken pride of place, we can conclude that adipose tissue is a component of the pathogenesis of MS, which demonstrates the importance of body fat distribution, especially visceral. As a risk factor fastest growing in prevalence and severity, and a negative aesthetic issue, obesity should be today a priority for public health. Due to its complexity, including clinical, epidemiological and psychosocial, requiring a comprehensive and multidisciplinary approach. Based on survey data, there are doubts about the existence of the association of obesity and metabolic syndrome. Experimental studies in humans and also show obesity is a risk factor capable of causing an increase in blood pressure. There is evidence on the involvement of insulin resistance and hyperinsulinemia, although not yet available long-term prospective studies that can provide one. Insulin resistance is associated particularly with abdominal distribution of body fat. It is believed that the high cardiovascular risk attributed to intra-abdominal adiposity is related to the development of metabolic syndrome, which is attended obesity and hypertension among others. This work had as main objective to define and describe the metabolic syndrome, as well as its causal factors, consequences and treatment. The methodology was systematic literature review from the databases indexed in LILACS, BIREME, Medline and others. Conclusion: The metabolic syndrome may therefore be defined as a chronic degenerative metabolic disease characterized by association between insulin resistance, hypertension, dyslipidemia, diabetes mellitus type 2 (DM2), and other metabolic abnormalities. And, being a metabolic syndrome, it is important that the pharmacist know this disease and the health damages caused by it, so it can be diagnosed and treated correctly associating drugs, diet and physical activity provide a better physiological condition, health and quality of life for individuals.
- Track 15: Patient Care Technology
Location: Grand Ball Room-A
Chair
Stig Larsen
Norwegian University of Life Science, Norway
Co-Chair
Bård Dalhøi
Head Eye Active Diagnostic Systems, Norway
Session Introduction
Stig Larsen
Norwegian University of Life Science, Norway
Title: A new anti-cancer substance normalizing the blood picture in patients suffering from metastatic breast cancer stage IV
Biography:
Stig Larsen has completed his DSc in Clinical Research Methodology at Ullevål Hospital, Oslo University, Norway. He is Professor at the Norwegian University of Life Science and has published more than 300 papers in international medicine and clinical research methodological journals.
Abstract:
BP-C1 is currently used in treating metastatic breast cancer patients, controlling tumor growth, improves quality of life with a few mild side-effects. Methods: The material consists of laboratory results from 47 patients in two controlled clinical trials with daily IM injections of BP-C1 for 32 days. Study I was performed as an open non-randomized, Phase I dose-response study with a 3-level between-patient Response-Surface-Pathway design. The second study as a randomized double-blinded and placebo controlled multicenter study with stratified semi-cross-over design. Results: Hemoglobin and hematocrit increased significantly (p<0.01) during BP-C1 treatment, while red blood cell count increased but not significantly, the most pronounced increase was in anemic patients (p≤0.01). White blood cell count and neutrophils increased significantly (p= 0.01) in the total material. These variables (p<0.01), eosinophils (p=0.05) and monocytes (p<0.01) increased significantly and markedly in patients with lowest baseline levels. Additionally, low levels of thrombocytes significantly increased. No changes in liver parameters, amylase, glucose, creatinine, or albumin were detected except for albumin in the subgroup with low baseline, where levels increased significantly (p=0.04). An increase in K+, Ca2+ and PO4 3- was most pronounced in patients with low baseline levels (p≤0.02). A similar pattern detected for Mg2+, PT, KFNT and CRP increased significantly (p≤0.05) in the groups with the lowest values. Conclusion: Our findings support the safety profile of BP-C1 and did not induce to anemia, infection, bleeding, hepatic insufficiency or electrolyte imbalances, but corrugated abnormalities.
Gunnard K. Jacobson
Lesaffre Yeast Corporation/Lesaffre Human Care/USA
Title: Saccharomyces cerevisiae CNCM I-3856: a new strategy to improve abdominal pain/digestive discomfort
Time : 15:30-15:50
Biography:
Gunnard has over 30 years of experience with industrial yeasts and supplies technical support to the Lesaffre Group’s US operations and Lesaffre Human Care. He has a Ph.D. in microbial physiology from Oregon State University. He has experience in yeast mutational genetics and has been actively involved in strain development of industrial yeast for multiple applications. Recently, he has been involved in the use of fortified yeasts for human nutrition and probiotic microorganisms for the promotion of human well being.
Abstract:
With a worldwide prevalence of 5-20%, Irritable Bowel Syndrome (IBS) is associated with high direct and indirect health costs. Its pathogenesis remains unclear, the efficacy of available treatments is modest and short-term, and their tolerance is poor. Saccharomyces cerevisiae CNCM I-3856, proprietary to Lesaffre, has been evaluated in a randomized, double blind, placebo-controlled clinical trial in 179 adults with IBS according to Rome III criteria. Patients received either 500 mg of CNCM I-3856 daily or a placebo for 8 weeks followed by a 3-week washout period. After a 2-week run-in period, cardinal symptoms (abdominal pain/discomfort, bloating/distension, flatulence, bowel movement difficulty) and changes in stool frequency and consistency were recorded daily and assessed each week. In the last 4 weeks of treatment, the proportion of responders, defined by an improvement of abdominal pain/discomfort, was significantly higher (p = 0.04) in the CNCM I-3856 group than the placebo group (63% vs. 47%). These clinical results were strengthened by multiple-choice questionnaires evaluating consumer satisfaction of Ibsium®, a CNCM I-3856 food supplement. Upon physician recommendation, 1161 patients consumed one Ibsium® capsule per day for a 1 to 3-month period. 96% reported a significant improvement of their symptoms (mainly abdominal pain (64%) and bloating (70%)), and, for 77% of subjects, this improvement was obtained within the first 5 to 15 days of consumption. 99% of consumers reported that they tolerated the product well. Ibsium® (Saccharomyces cerevisiae CNCM I-3856) is a natural, well-tolerated solution for the long-term management of abdominal discomfort; offering relief without side effects or habituation.
Bård Dalhøi
Vice President R&D at Heads AS, Norway
Title: Reliability and Validity of an eye tracking technology
Time : 14:10-14:30
Biography:
Bård Dalhøi D.O. (Dr. Osteopathic Manual Medicine) ongoing PhD studies, and co-founder of Heads AS, Norway. Vice President R&D at Heads AS. Company has ongoing R&D for new certified medical technology. Products sold in research and in clinical medical professions like ENT, Neurology, Ophthalmology, Optometry and Emergency Room. The company has ongoing collaboration with EU medical universities, USA Optometry Universities and Vision Research Foundation/Eye Hospital in India.
Abstract:
A new prototyped eye tracking technology with functional oculomotor disorders and reading disabilities is introduced. The aim is to investigate intra and inter reliability of oculomotor functions expressed in eye saccades and smooth pursuits. Material: The reference population consists of children and adults of both genders between five to 70 years of age with normal or dysfunctional conditions in eye movements, classified by the optometrist. The study sample consisted of six controls and 12 oculomotor disabled subjects related to age and dysfunction. Methods: The dysfunction was classified as “normalâ€, “mildâ€, “moderate to severeâ€. The study was performed as a randomized observer blinded trial with stratified, nested Latin squared design. The sequence of investigation was allocated by a 3x3 Orthogonal Latin square. Results: Kappa analysis was performed and intra agreement for both the optometrists and the eye tracker were classified as “Very goodâ€. Additionally, the agreement between the eye tracker and each of the two optometrists were found classified as “Goodâ€. Conclusion: the eye tracker seem to be a reliable and valid method to measure oculomotor functions in eye saccades and smooth pursuits
Julia A. Greenawalt
Indiana University of Pennsylvania,USA USA
Title: Meaningful Use, Documentation of Nursing Care, and Lessons Learned When a System Goes Off-Line
Time : 10:20-10:40
Biography:
Julia Greenawalt is working as a Asst. Professor at Indiana University of Pennsylvania. She completed her education in University of Pittsburgh. Her work experience on Clinical Research, Public Health
Abstract:
Teaching documentation skills and concepts to the emerging professional is a new challenge for nurse educators as the infusion of meaningful use is implemented within nursing's affiliating agencies. Discipline mandates and accreditation requirements expect the emerging professional to be current in technology and communication as one prepares to care for patients in contemporary times. This presentation will share how meaningful use has been incorporated into one obstetrical course in a baccalaureate nursing program. This is necessary for other disciplines to understand how and where meaningful use impacts their operations. In addition, we will discuss some of the current challenges as we go forward pulling from real life experiences of one nurse faculty member’s exposure to the infusion of meaningful use into course and practicum, events when meaningful use goes inactive and operations remain ongoing, and the actions taken to mitigate future safety and sentinel events. This experience illuminates the need for inter-professional on-going collaborative efforts to enhance patient safety from an informatics perspective. However, the best method of instruction for teaching learning to undergraduate nursing students as relates to electronic documentation remains unclear at this time. Current inquiry and future research into evidence-based practice are needed as preparation gears toward workforce ready graduates who will be skilled and adept at documentation using current technologies. Teaching skills for information systems, particularly the electronic health record, requires identification of challenges and obstacles, which can be surmounted if academe and corporate culture work in tandem.
Espen Glomsrad
Norway
Title: Osteopathic treatment of patients suffering from chronic non-specific low back pain: A dose- response pilot study.
Time : 14:50-15:10
Biography:
Espen Glomsrød has completed his MSc in 2013 from University of Bergen, Norway. From 2002-2013 he worked as a teacher of osteopathy in Nordisk Akademi for Ostopati and Norges Helsehøyskole Campus Christiania, Oslo, Norway. He works as an Osteopath DO (eur.) MSc in a private clinic in Halden, Norway.
Abstract:
Background: Dose- response studies are needed for pharmaceuticals, but have not been commonly performed in the field of manual therapy. Objective: The aim of this study was to determine the combination of treatment numbers and intervals needed to obtain the optimal effect of osteopathic treatment for patients with chronic non-specific low back pain. Design: The study was performed as an open, randomized, single -centre trial with a 22 factorial design. Methods: The patients were allocated equally to four groups by block randomization. The first group was given two treatments at an interval of 14 days, the second group was given two treatments at an interval of seven days, the third group received four treatments with intervals of 14 days, and the fourth group received four treatments with intervals of seven days. Oswestry Disability Index (ODI) and the Numeric Rating Scale (NRS) were recorded at baseline and two weeks post treatment. Participants: Eight women and four men with chronic non-specific low back pain were included. Results: The two treatments with an interval of 14 days resulted in an ODI reduction of only 1.3 (95% CI: -21 – 24.1). The largest reduction in ODI was detected in the four treatments with the seven days intervals. The mean reduction in this group was found to be 19.3 (95% CI: -14.4 – 53.1). An interaction between the number of treatments and the treatment interval was observed. Conclusion: The effect increased with increases in the numbers of treatment and reductions in the treatment interval. The program with four treatments and intervals of seven days was found to be optimal among the four examined regimens.