3^rd International Conference on Clinical Pharmacy December 07-09, 2015 Atlanta, USA

Biography:

Dr. Yousef Alomi, Head of General Administration of Pharmaceutical Care Administration, and Head of National Drug Information Center, MOH Saudi Arabia Dr. Alomi is a product of King Saud University confirmed with the degree of Bachelor of Pharmaceutical Sciences in the year 1992. After six-years of higher study, he earned his Master of Clinical Pharmacy from the same university in the 1998. He is an affiliated clinical instructor of Purdue University in the USA. He is adjunct assistant professor of King Saud University college of Pharmacy. Dr. Alomi worked as clinical pharmacist in critical care area and nutrition support. He is He is establish and implement several programs at MOH Hospitals at first time; Clinical Pharmacy Program, Medication Safety Program, Pain Management Program, Anticoagulation Program and Pharmacy Infection Control, including 30 Adult and 20 Pediatrics Clinical Pharmacy Program; he founder of Mass Gathering Pharmaceutical Care in Saudi Arabia. He became a member of advisory board of the Arab Pharmaceutical Journal in 2010. He became as Pharmacy Board Member of Saudi Commission of Health Care Specialities2010-2013. He had several research papers in clinical Pharmacy and Pharmacy practice published in ACCP and ISPOR conferences; He had several presentations in the clinical pharmacy and pharmacy practice at several conferences in and outside Saudi Arabia.

Abstract:

National antimicrobial stewardship is continuous work to optimize Antimicrobial usage to improve patient outcomes and prevent antimicrobial related Problems. General Administration of Pharmaceutical care established the program in 2013 by formulate Central Antibiotic Committees, this committee established National Antimicrobial Stewardship program consisting of formulating peripheral antibiotics, infectious diseases team, antibiotics physician order form, antibiotics consumption and usages, antibiogram regulations, and USA General of disease control antimicrobial stewardship monitoring outcome indicators. In 2014, Peripheral Antibiotics Committees were established at twenty regions to follow up the implementation of the program national wide, and started with antimicrobial stewardship education and orientation. In 2015, the real applications of the program was started in more than ten region and more than forty hospitals. Antimicrobial stewardship will be expanded to cover 20 regions and more ninety biggest hospitals, medical cities and privates hospital and primary care centers in Saudi Arabia. The program is excepting to reduce antimicrobial consumption more than 50% with reduction of bugs resistance to medication, reduction of antimicrobial related problems, better patients care with tremendous reduction of unnecessary cost.

Biography:

Dr. F. I. Al-Saikhan has completed his bachelor in pharmaceutical sciences at age of 23 from King Saud University in Riyadh, K.S.A., PharmD from St. Louis College of Pharmacy at age of 27 from St. Louis College of Pharmacy in St. Louis, MO. He has completed ambulatory care residency at Oklahoma Uni. He worked as a hospital pharmacist, then consultant clinical pharmacist and director of pharmacy services at KKESH-Wilmer Eye Institute (John Hopkins hospital-Baltimore) then assistant professor at PSAU. He has published several research papers in reputed journals and was invited to speak at several professional meetings. He serves as a consultant at different organization

Abstract:

Background: The increased influx of patients and limited access to specialized healthcare due to insufficient number of medical staff in ophthalmology setting has been reported for more than a decade. For same reason, our pharmacy services introduced clinical pharmacists as an alternative healthcare provider for routine patient’s visits in such setting. Aim: The aim of this study was, to allow ophthalmology medical staff to focus on more important patients’ needs and also to explore the potentials of clinical pharmacist engaged in the ophthalmology clinic. Method: This study assessing the potential impact of several problems for patients suffering from eye disorders that usually encounter and must visit the ophthalmologists for help. Among which is chronic medications’ supply. Step-by-step protocols for 65 of the most frequently prescribed ophthalmic drugs were developed to guide the clinical pharmacist in decision-making. Results: Over a period of 15 months, the refill clinic was responsible for reviewing 8,572 medical records with an average review time of 5.5 minutes per chart. Based on an average 8-hour workday, this study saved and equates approximately 98 days per 15 month about (23%) that returned to clinicians for patients in greater need of their immediate expertise. The rate of pharmacist chart intervention was 16.3%. Conclusion: This experience was very successful for dispensing ophthalmic drugs safely, and saving patient and clinician time. I recommend this to be expanded to include additional and advanced clinical specialty.

Biography:

Marie Smith, Palmer Professor and Asst. Dean, Univeristy of Connrecticut School of Pharmacy, is a nationally-recognized scholar in the area of primary care practice transformation and health policy. She completed a sabbatical at the CMS Innovation Center in 2013 and has facilitated the Practice Transformation Taskforce with the CT Healthcare Innovation Office. She is a frequent invited speaker for international, national, and regional conferences; she has published landmark articles on the role of pharmacists in medical homes and accountable care organizations in Health Affairs (premier health policy journal) and serves on the AHRQ Study Seciton for Healthcare Quality and Safety.

Abstract:

Objectives: To assess the current knowledge of consumers and physicians about pharmacist training/expertise and capacity to provide primary care medication management services in a shared resource network; determine factors that will facilitate/limit pharmacists as a member of community-based “health care team;” determine factors that will facilitate/limit pharmacists integration in primary care teams; determine factors that will facilitate/limit payer reimbursement for medication management services. Methods: Qualitative research methods; focus groups were conducted with primary care physicians and consumers, while semi-structured discussions were conducted with a public and private payer. Results: Consumers viewed pharmacists in traditional dispensing roles and were unaware of the direct patient care responsibilities of pharmacists as part of community-based health teams. Physicians noted several chronic disease states where clinically-trained pharmacists could collaborate as health care team members yet had uncertainties about integrating pharmacists into their practice workflow and payment sources for pharmacist services. Payers were interested in having credentialed pharmacists provide medication management services if the services improved quality of patient care and/or prevented adverse drug events, and the services were cost neutral Conclusions: Pharmacists must disseminate the existing body of evidence on pharmacists as direct patient care providers of medication management services and the related impact on clinical outcomes, patient safety, and cost savings to external audiences.

Biography:

Dr. Elnour has received his PhD in School of Pharmacy, Queen’s University Belfast, N. Ireland-United Kingdom during the period of 2000-2004. Currently, he is working as Adjunct Clinical Associate Professor in Pharmacology Department at United Arab Emirates University. He is serving as an editorial member of several reputed journals like Journal of Medicine, Institute of Research Engineers and doctors, Journal of Pharmacy Research, International Journal of Biomedical Sciences and Bioinformatics, Symbiosis Journal of Pharmacy and Pharmaceutical Sciences, Pharmacology and Pharmacy, International Journal of Medical Sciences and Biotechnology. He has authored 31research articles, Meta-analysis and Editorial Letters. He is a member of several professional and therapeutics committees like Clinical pharmacy Council, Al Ain hospital representative, SEHA, Abu Dhabi and chairperson for Team Leader of Pharmacy and Therapeutic Committee (PTC) – Drug Utilization Evaluation Subcommittee (DUES).

Abstract:

Objective: The study objective was to design and implement an educational program to raise the awareness of in-patient nursing staff about medication errors and other medication-related safety issues. Method: A sample of in-patient nursing staff in Al Ain Hospital (n=370) was included in the study and completed a self-reported questionnaire about medication errors. A structured program was developed and used by the clinical pharmacists to identify the nursing knowledge on medication errors and other medication-related safety issues. The program consisted of a pre/post self-reported questionnaire, a training service, educational material, successive presentations and handouts. The self-reported questionnaire included twenty closed questions asking nurses opinions about medication errors. A training program on medication safety (Med Safe tool) was carried out by [clinical pharmacy team (n=2) and quality coordinator nurse (n=1)], for each group of 10 nurses. Main outcome measure: The study outcomes were the change in mean scores pre and post intervention. Results: Findings revealed differences in the knowledge of nurses about the causes and reporting of medication errors. There were statistically significant differences in responses across the participant’s years of experience and the current clinical working area. The participant’s responses improved significantly [57.4%±8.2, (95% CI: 56.6-58.2) vs. 68.9±10.3, (95% CI: 67.8-69.9); p<0.05] pre and post questionnaire, respectively. Conclusions: The clinical pharmacist’s structured program has improved knowledge of the in-patient nursing staff in terms of raising their awareness about medication errors.

Biography:

Mohamed Abd-Elghany Abd-Elaziz has completed PhD in Clinical Pharmacology, College of Medicine, Mansoura University, Egypt, 1989. He is Professor of Clinical Pharmacology, Mansoura Faculty of Medicine, 2001, June, and has been the Head of Clinical Pharmacy Department, Faculty of Pharmacy, Salman Bin Abdulaziz University, Saudi Arabia, since October 2011. He has published more than 40 papers in reputed journals and is serving as an Editorial Board Member of repute. His area of interest is drug genotoxicity and hospital pharmacy.

Abstract:

Purpose: To review and understand types and pattern of antibiotic prescribed for patients admitting university hospital, in Alkharj, Saudi Arabia. Methods: Retrospective study using clinical data on antibiotic prescriptions in 925 patient cases chosen from 2500 patients admitting to university hospital by systematic sampling. All the antibiotic prescriptions written for therapeutic purposes were assessed and reviewed over the period of six months (from 1/06/2013 to 30/12/2013) in Alkharj, university Hospital, KSA. Data including patient’s demographic characteristics, clinical diagnosis, and the type of antibiotic administration were studied and analyzed. Results: Antibiotics were prescribed to 56.9% of patients, among which 55.7% were prescribed two or more kind of antibiotics. Two drugs were prescribed to 74%, three drugs for 22% and 4 or more than 5 drugs for only 4% of studied sample. Cephalosporin (73%) ranked first followed by quinoline (67%) then penicillin’s (42%). Conclusions: Further, long term and more detailed studies investigating antibiotics usage in Saudi Arabia, in an attempt to make rational choices for antibiotic use and recognize the potential problems of antibiotics abuse.

Biography:

Abdul-Aziz Elshemary has completed his MBBcH from Northern borders University, Saudi Arabia. He is now working as a Resident Physician at Military Hospital in Riyadh, KSA. He is working on elaborating many researches for publishing with his staff members in the University.

Abstract:

Background & Aim of the work: Ulcerative Colitis (UC) is a chronic Inflammatory Bowel Disease (IBD). The hallmark of UC lesions is infiltration of the intestine by mononuclear cells, predominantly lymphocytes. This cellular infiltration is the result of increased leukocyte recruitment and proliferation in the inflamed colon. Adhesion molecules are cell surface-expressed glycoproteins that mediate cell-cell and cell-extracellular matrix interactions. They play a prominent role in leukocyte recruitment. Adhesion molecules, therefore, represent promising therapeutic targets for human inflammatory diseases, including UC. The arginase (AR) has gained attention in studies focusing on the pathophysiology of IBD. The aim of the present descriptive study is to investigate the serum level of the adhesion molecules (ICAM and E-selectin) and arginase enzyme of patients diagnosed with UC in central hospital, Arar, Saudi Arabia to illustrate the magnitude of UC problem in northern border region of Saudi Arabia and to confirm the role of adhesion molecules and arginase in pathogenesis of UC in these patients. Methodology: The study is a retrospective study of 24 cases of UC diagnosed and followed up in central hospital in Arar, Saudi Arabia, from January 2015 to July 2015. Samples of blood were taken from the diagnosed cases for measurement of serum levels of ICAM, E-Selectin and arginase enzyme by Enzyme-Linked Immunosorbent Assay (ELISA) in addition to C-Reactive Protein (CRP). Results: Compared to control groups formed by individuals without clinical and/or laboratory signs of UC, UC patients showed significant increased levels (p<0.001) of sICAM-1, E-selectin and CRP in serum samples. On the other hand, arginase serum levels decreased significantly in sera of UC patients. Conclusion: In conclusion, the present work confirmed the role of adhesion molecules notably ICAM and E-selectin and the acute phase biomarker CRP in pathogenesis of UC and suggested a protective effect of arginase enzyme in reducing inflammation in colitis. Anti-adhesion molecules targeting ICAM and E-selectin may be promising for treatment of UC.

Biography:

Sathish Amirthalingam holds BPharm, MPharm, PhD and PGDHM degrees. He is a Clinical Pharmacist from India and is currently working in International Medical University, Malaysia. He was a state first and distinction Research Scholar in Post-Graduation level. He has a teaching and professional experience of 13 years in the field of pharmacy. He received 6 awards from various bodies from pharmacy fields including state and national levels for Best Research Paper and Research Project. He had written 2 books in pharmacy field like clinical pharmacy and pathophysiology for pharmacy students. He has published 21 national and international papers, 2 copyright of his innovative clinical software and has presented 18 papers in national and international conferences. He has guided 4 Under-Graduate, 8 Post-Graduate projects and he is guiding 4 more Under-Graduate projects currently. He is also associated with Life Member in various professional bodies like IPA, IHPA and was a Member of Board of Studies in Department of Pharmacology, S P University.

Abstract:

A large number of drugs are introduced every year and new interactions between medications are increasingly reported. Clinically significant drug interactions can occur when two or more drugs are taken in combination. DDIs may lead to adverse drug reactions that can be severe enough to necessitate hospitalization. The outcome can be harmful if the interaction causes an increase in the toxicity of drugs. Managing drug interactions in hospitalized patients is important and challenging. Recognizing drug interaction is a daily challenge for family physicians and remembering all potential interactions has become virtually impossible. Drug therapy is growing more complex, thus making appropriate drug prescribing increasingly challenging. More than 30 medications are introduced each year and new interactions between medications are increasingly reported. Consequently, it is no longer practical for physicians to rely on memory alone to avoid potential drug interactions. Safety is an essential principle of patient care; therefore, the Fifty-fifth World Health Assembly underlined the importance of promoting science based systems to improve patient safety and the quality of health care. Drug information increases at accelerating rate annually. Checking manually for drug interactions becomes more time consuming and error-prone. The use of computerized drug interaction screening system has been debated due to many false alerts, quality of the data held in the software. We compare the various drug interaction databases available in online and few of offline software revealed that, the entire software data base contains only limited drugs with its interactions of internal analysis. Our research created new outlook of drug interaction

Biography:

Dr. Sathish Amirthalingam, B.Pharm., M.Pharm., Ph.D., PGDHM., is a clinical pharmacist from India and currently working in International Medical University, Malaysia. He was a state first and distinction research scholar in Post-Graduation level. He has a teaching and professional experience of 13 years in the field of pharmacy. He received 6 awards from various bodies from pharmacy fields including state and national levels for best research paper and research project. He had written 2 books in pharmacy field like clinical pharmacy and pathophysiology for pharmacy students. He has published 21 national and international papers, 2 copyright of his innovative clinical software and he has presented 18 papers in national and international conferences. He has guided 4 under graduate, 8 post graduate projects and he is guiding 4 more under graduate projects currently. He also associated with life member in various professional bodies like IPA, IHPA and he was a member of board of studies in Dept. of pharmacology, S. P. University.

Abstract:

A large number of drugs are introduced every year and new interactions between medications are increasingly reported. Clinically significant drug interactions can occur when two or more drugs are taken in combination. DDIs may lead to adverse drug reactions that can be severe enough to necessitate hospitalization. The outcome can be harmful if the interaction causes an increase in the toxicity of drugs. Managing drug interactions in hospitalized patients is important and challenging. Recognizing drug interaction is a daily challenge for family physicians and remembering all potential interaction has become virtually impossible. Drug therapy is growing more complex, thus making appropriate drug prescribing increasingly challenging. More than 30 medications are introduced each year and new interactions between medications are increasingly reported. Consequently, it is no longer practical for physicians to rely on memory alone to avoid potential drug interactions. Safety is an essential principle of patient care; therefore, the Fifty-fifth World Health Assembly underlined the importance of promoting science based systems to improve patient safety and the quality of health care. Drug information increases at accelerating rate annually. Checking manually for drug interactions becomes more time consuming and error-prone. The use of computerized drug interaction screening system has been debated due to many false alerts, quality of the data held in the software’s. We compare the various drug interaction databases available in online and few of offline software’s revealed that, the entire software data base contains only limited drugs with its interactions of internal analysis. Our research created new outlook of drug interaction software named as Dr.DRINSOTM and uploaded with drugs available with standard source of drug interaction materials.

Biography:

Prof. Stig Larsen has completed his DSc in Clinical Research Methodology at Ullevål Hospital, Oslo University Norway. He is professor at the Norwegian University of Life Science and has published more than 300 papers in international medical and clinical research methodological journals.

Abstract:

The aim was to compare the efficacy and tolerability of a new benzene-poly-carboxylic acids complex with cis-diammineplatium (II) (BP-C1) versus equal looking placebo in treatment of metastatic breast cancer patients. Material and Methods: A randomized, double blind, placebo controlled multi-center study was performed with semi-cross-over design. Patients allocated to placebo switches to BP-C1 after 32 days of treatment. Thirty patients were given daily intramuscular injection of 0.035 mg/kg bw BP-C1 or placebo in 32 days. Biochemistry, hematology, NCI Bethesda (CTC-NCI), EORTC QOL-C30&BR23 recorded at screening and after every 16 days of treatment. CT performed at screening and every 32-day. Results: The sum of target lesions increased 2.4% in the BP-C1 group and 14.3% in placebo. The increase in the placebo group was significant (p=0.013) but not in BP-C1. The difference between the group was significant in favor of BP-C1 (p=0.04). Significant difference (p=0.026) in favor of BP-C1 regarding RECIST classification. CTC-NCI toxicity score increased non-significantly in the BP-C1 group, but significantly in placebo (p=0.05). “Breast cancer related pain and discomfort” and “Breast cancer treatment problem last week” were significantly reduced (p=0.02) in the BP-C1 group and slightly increased in placebo. Significant difference in favor of BP-C1 (p=0.05). “Breast cancer treatment problem last week” was significantly reduced in the BP-C1 group (p=0.02) and slightly increased in placebo. “Breast cancer related pain and discomfort”. Conclusion: BP-C1 reduces the cancer growth, is well tolerated, improves quality-of-life and has few mainly mild AE in patients suffering from stage IV MBC.

Biography:

Samah ElSalem has completed her BSc Pharm (2011) and her PharmD (2012) from the College of Pharmacy, Qatar University. Since 2012, she has been working as a Clinical Pharmacist in Women’s Hospital, Doha, Qatar. She has been involved in several researches in the field of clinical pharmacy and has published some of her work in peer-reviewed journals.

Abstract:

Objectives: To conduct a drug-use evaluation by investigating indications, appropriateness of dosing, and clinical outcome of misoprostol-only regimen when used for medical evacuation of spontaneous abortion. Method: A retrospective descriptive drug-use evaluation was conducted on women with spontaneous abortion who received misoprostol for medical evacuation during August 2013. The current practice at Women’s Hospital was compared with World Health Organization (WHO) recommendation. Patients were stratified into three groups based on weeks of amenorrhea. Results: One-hundred and seven patients received misoprostol during August 2013. Thirty-three patients (31%) were included. In these patients, the main indication for using misoprostol was missed abortion (54.5%). In the group of ≤9 weeks, 80% of them received an initial dose of 800 mcg, 80% received frequency within WHO recommendation, and most of them had surgical evacuation (80%). In the group of 10 to 12 weeks, more than 80% received an initial dose of 800 mcg, 6% received frequency as WHO recommendation, and more than 75% had successful medical evacuation. In the group of 13 to 22 weeks, more than 80% of them received an initial dose of 400 mcg, more than 80% received frequency within WHO recommendation, and 54% of them had successful medical evacuation. Overall, more than 70% of patients received ≤3 total doses of misoprostol and more than 60% had successful medical evacuation as a clinical outcome. Conclusions: Despite that the current practice at Women’s Hospital was not always in accordance with WHO recommendation; successful medical evacuation was achieved in most patients.

Biography:

Menyfah Al Anazi is a pharmacist currently working at the Drug policy and Economic Center of Ministry of National Guard – Health Affairs. She has completed Clinical Pharmacy Practice since 2007, and certificated in Clinical Research Coordinator since 2009.

Abstract:

BACKGROUND: Suicidal behaviors are among the leading causes of death worldwide. AIM: to assess the cases of suicide among children, potential risks, and outcome METHOD: Using a retrospective chart review of children who diagnosis with intentional poisoning between 2009 and 2011, RESULTS: We identified 10 cases of suicide among children (mean age 12 years, SD 1.98, range 8 to 14 years) 0.66% of poisoning cases in pediatric. The female: male ratio was 1:1. The majority of cases were middle social/economic class (n = 9; 90%). Chemical constituted the most commonly encountered group of toxins 60 %( mainly Clorox 50%) and drugs 40% (mainly acetaminophen 20%). Home Chicken was the commonest place of poisoned (50%); summer was the most common season of poisoning (40%) and Thursday most common day. Mothers of (90%) the children poisoned worked in the home. Symptomatic cases on admission were 80%, GI complication representing 60% and neurology 30% of the complication. Most of the poisoned cases undergo complete recovery and discharged from ER (60%) and 40% were hospitalized, the mean hospital stay was 2 days, and ranged from 0 to 9 days. There was a statistically significant difference between the lengths of stay of patients in terms of hospital cost (P < 0.05). CONCLUSIONS: The results point to the need to increase our understanding of the suicidal behaviors during childhood/adolescence and of the causal pathways linking these behaviors to child-adolescent mental disorders. During routine care visits, pediatricians should be skilled to recognize risk factors for adolescent suicide in order to intervene appropriately

Biography:

Marília B. Visacri was born in São Paulo, Brazil, in 1989. She got her Pharmacist grade and her Master Degree in Medical Sciences by the State University of Campinas/Brazil in 2011 and 2013, respectively. She is currently a Ph.D Student at the Department of Clinical Pathology of the School of Medical Sciences from the same university. Her main research interests include clinical pharmacy, pharmaceutical care, pharmacovigilance, oncology and oxidative stress. Furthermore, she has publications in the areas of pediatrics and HIV/AIDS.

Abstract:

The most common treatment for patients with advanced head and neck cancer is chemotherapy with high doses of cisplatin and concomitant radiotherapy. The aim of this study was to determine the impact of cisplatin doses on toxicities and response to therapy in advanced head and neck cancer patients. It was an observational and prospective study at a hospital in Brazil where head and neck squamous cell carcinoma (stages III-IV) patients who received chemoradiation (80 or 100 mg/m2 of cisplatin per cycle) and completed 3 cycles were included. Two groups were studied considering the accumulated dose: G1 (280-300 mg/m2) and G2 (240-260 mg/m2). Audiometry was performed to evaluate ototoxicity and creatinine clearance to nephrotoxicity; severities were classified by CTCAE (v.4). Computed tomography and RECIST 1.1 were realized for treatment response. Forty patients were studied (G1: n=23; G2: n=17). There was a prevalence of male (90.0%), white (92.5%), Karnofsky Performance Scale 90-100% (63.2%) and had pharyngeal tumor (67.5%) in stage IV (85.0%), with a mean age of 52.9±7.5 years. Ototoxicity was present in 69.4% in G1 and 94.1% in G2, with a prevalence of grade 3 for both. In G1, 39.1% had nephrotoxicity versus 47.1% in G2, mostly grade 1. A complete response to treatment was observed in 8.7% in G1 and 3.5% in G2. For all outcomes there was no statistically significant difference between groups. In conclusion, the cisplatin doses had no statically significant impact on studied outcomes, however, a prevalence of complete response and toxicity was observed in G2.

Biography:

Joachim Roland Kaufmann has completed his MSc 2004 at the University of Greenwich / GB and the European School of Osteopathy (ESO), Maidstone / GB. He is the owner of Bergen Osteopatiklinikk and Korpus Berlin - clinics for treatment of injured athletes and other muscle skeletal pain, is a teacher at different Schools in the Manual field in Europe over 20 years. He is a part of the coaching staff of the German Basketball National team since 2000 and worked in different medical staff from soccer to track and field. Now he is in a PhD project in Norway.

Abstract:

The aim of the study was to determine the combination of “number of treatments” and “interval between treatments” in order to optimize the effect of Osteopathic treatment of foot related pain. Material & Methods: The material consists of 32 female and 22 male patients with a mean age of 42 years and a BMI of 27.0. The study was performed as an observer blinded, randomised single centre trial with 32-factorial design. “Number of treatments” and “Treatment intervals” was used as the two factors. The patients were allocated to treatment groups by nested block randomisation. The primary variables “Pain at rest” and “Pain at load” were recorded on 10 cm Visual Analogue Scales and the Ankle-Brachial Index. Results: Four treatments with seven days treatment interval were the superior combination regarding reduction in pain at rest (p<0.01). Four treatments gave also significant (p<0.01) reduction in pain at load both for seven and ten days treatment intervals, but 10 days treatment intervals were the superior combination for reduction in pain at load. Number of treatments seems to be the dominant factor regarding both pain reductions at rest and at load. The study detected an obvious interaction between the two factors. By increasing the number of treatments, the duration between treatments has to be increased similarly. Conclusion: The combinations for obtaining the largest pain reduction at rest and load seem to be four treatments with seven and ten days treatment intervals, respectively.

Biography:

Abdulaziz A Saddique has a Bachelor of Pharmacy Degree from King Saud University and Doctorate degree in Clinical Pharmacy from the University of Minnesota. He is a Certified Clinical Toxicologist and Clinical Pharmacy Specialist in Intensive Care, also is a Certified Professional in Health Care Quality (CPHQ), California, USA and Certified Six Sigma Master Black Belt. He is a member of King Abdulaziz Quality Award, Committee, and Healthcare Standards Committee Ministry of Health. He published seven books on Quality Management, Pharmacy, and Toxicology and more than 100 papers in national and international journals.

Abstract:

Clinical pharmacy is a unique service provided by the leading pharmacy departments in the United States. The concept of clinical pharmacy evolved after the significant increase in number of pharmaceuticals in the market and the increasing potential of drug interactions. However, the clinical pharmacists are not merely the individuals who advise on the drug interactions. There are number of functions which include but not limited to; design of appropriate drug therapy, pharmacokinetics assessment and evaluation to optimize drug therapy, drug information dissemination to the physicians and other healthcare providers and participate as toxicology consultant in poison management. At King Khalid University Hospital (KKUH), the first clinical pharmacy services program began in 1983. The aim of this study is to evaluate the impact of our clinical pharmacy program on the patients’ care as well as its perception by the medical staff that came from different parts of the World. Our clinical pharmacists were asked to record any suggestions or interventions in the form. The forms were all collected at the end of each day and entered into a database for analysis. Each intervention was analyzed in order to assess the merit of the action in terms of the therapeutic, financial and direct cost impact. The study showed a positive impact on the patients’ care as well as on the economy of drugs prescribing. Meanwhile, the service was very much appreciated by the medical staff as well as other healthcare providers.

Biography:

Shinya Uchida received his PhD degree from the University of Shizuoka in 1999. He served as a Clinical Pharmacist at the University Hospital of Hamamatsu School of Medicine. At present, he is an Associate Professor at the University of Shizuoka and his major interests include clinical pharmaceutical science, clinical pharmacology and pharmacokinetics. He has published 69 papers in peer-reviewed journals.

Abstract:

A “cocktail” approach involving the simultaneous administration of multiple cytochrome P450 (CYP)-specific probes concurrently detects the activity of multiple CYP enzymes. We developed and validated a rapid and selective liquid chromatography tandem mass spectrometry (LC-MS/MS) method to determine the plasma concentrations of 5 CYP probe drugs and metabolites (caffeine/ paraxanthine, CYP1A2 substrate; losartan/losartan carboxylic acid (E3174), CYP2C9 substrate, omeprazole/5-hydroxy omeprazole, CYP2C19 substrate; dextromethorphan/dextrorphan, CYP2D6 substrate; and midazolam/1’-hydroxymidazolam, CYP3A4 substrate) by a single-step extraction followed by a single LC-MS/MS run. The assay had high accuracy and reliability for plasma samples. Next, we clarified the chronological changes in rifampicin-induced CYP enzyme activity after rifampicin discontinuation because the time course after drug treatment discontinuation has received little attention. Thirteen volunteers were administered rifampicin (450 mg) once daily, and the cocktail method was repeatedly performed. A 7-day rifampicin administration increased CYP2C19 and CYP3A enzyme activities. The induced CYP2C19 and CYP3A activities remained elevated at 4 days after rifampicin discontinuation and returned to baseline levels 8 days after rifampicin discontinuation. However, CYP1A2 and CYP2D6 enzyme activities showed no significant changes and CYP2C9 enzyme activity increased with rifampicin with a tendency toward statistical significance. These results suggest that drug interactions can occur even after rifampicin discontinuation. In conclusion, the advantage of our cocktail approach is that it enables in vivo assessment of the activity of various drug-metabolizing enzymes and the detection of potential drug interactions in a single assay.

Biography:

Ayman M Noreddin received his PhD in Pharmaceutical Sciences from the University of the Pacific, California and received research training as a visiting scholar at the Department of Medicine, Stanford University. He had Post-doctoral fellowship (Pharmacokinetics and Pharmacodynamics of Antimicrobials), Department of Medical Microbiology, University of Manitoba followed by an American College of Clinical Pharmacy postdoctoral fellowship (Infectious Diseases). His research interest includes Pharmacoklinetic/Pharmacodynamic modeling of anti-infective and anti-cancer therapy, clinical simulation and Monte Carlo analysis and bacterial resistance in biofilm studies. He has outstanding records of scientific and academic accomplishments with multiple research funding, numerous publications in highly prestigious journals and various presentations in both national and international conferences. He served as a scientific reviewer for the NIH as well as other national and international research institutions.

Abstract:

Introduction: Streptococcal pneumonia is a major cause of morbidity and mortality worldwide. Fluoroquinolones are one of the mainstay drugs for treatment of these infections. However emerging resistance poses a threat to the class’s future utility. Using Monte Carlo simulation, we evaluated the probable efficacy of ciprofloxacin, levofloxacin, gemifloxacin, garenoxacin, and moxifloxacin in eradicating infections and preventing continued growth of resistance.

Methods: Using patient data from strep pneumonia patients in hospitals and MIC data from the CROSS study; drug regimens were compared to see the likelihood of attaining fAUC0-24/ MICall ratios depicting goal clinical outcomes.

Conclusions: Very few regimens are able to prevent further growth of resistant organisms when ParC mutations have occurred. Only garenoxacin and moxifloxacin were able to eradicate extremely resistant isolates in serum and ELF respectively

Biography:

Sonia Amin Thomas (formerly Sonia Patel) is an Assistant Professor of Pharmacy Practice and Clinical Pharmacist. Her main focus in teaching is oncology (therapeutics) along with other courses at PCOM in Suwanee, GA and conducting an oncology practice site at North Fulton Hospital in Roswell, GA. She attended the University of Georgia for her Undergraduate coursework from 2004-2007 and then proceeded to complete her PharmD at South University School of Pharmacy from 2007-2010. Dr. Thomas completed a Post-Graduate year 1 general Pharmacy Practice Residency in Columbus, GA and received training through Post-Graduate year 2 oncology residency in Detroit, MI.

Abstract:

Healthcare workers are exposed to chemotherapy during preparation and administration of hazardous drugs including chemotherapy. This has been an ongoing concern for years in the healthcare industry. Various studies showing contamination in preparation area, long-term chromosomal abnormalities, biological marker changes in workers, long-term effects on reproduction, hair loss, rashes, miscarriages and birth defects and cancers due to chemotherapy exposure make this concern legitimate. There are guidelines for safe handling of both intravenous and oral chemotherapy from the American Society of Health-System Pharmacists (ASHP), the Oncology Nursing Society (ONS) and the Occupational Safety and Health Administration (OSHA) which all discuss how to prepare, handle and administer chemotherapy safely.

Biography:

Ahmed M. Abudief is working as a Sohag University, Sohag. And his research interest is on Chemical Kinetics, Inorganic Chemistry, and Physical Chemistry. And he has published 39 research articles

Abstract:

Air and moisture stable coordination compounds of first transition metals such as Co (II), Ni (II) and Cu (II) with newly designed Schiff base (bsiph) incorporating 5-bromosalicyaldehyde (bs) with isatin and 4-nitro-o-phenylene diamine (nph) have been synthesized. The molecular structure of ligand and its complexes were characterized by elemental analyses, IR, 1H and 13C NMR, TGA and electronic spectroscopy. Conductivity and magnetic susceptibility measurements were used to elucidate the structure of the newly prepared metal complexes. The analytical and spectroscopic tools suggested that the prepared Schiff base ligand behave as mono basic tetra-dentate ONNO ligand and bind to metal (II) ion in octahedral geometry according to the general formula [M(bsiph)x(H2O)].n(H2O) where M=Cu(II), Co(II) and Ni(II), x=OAC-, NO3- and n=number of hydrated water molecules. The binding properties of the investigated complexes with Calf thymus (CT-DNA) were investigated by using electronic spectra and viscosity measurements. Moreover, DNA cleavage activity of the prepared Schiff base complexes was monitored by gel electrophoresis. Furthermore, the Schiff base and its complexes were screened for antimicrobial activity against gram positive bacteria (Staphylococcus aureus), gram negative bacteria (Escherichia coli, Pseudomonas aeroginosa) and fungi (Aspergillus flavus, Candida albicans and Trichophyton rubrum). The results showed that the metal complexes were more reactive with respect to its ligand.

Biography:

Yuyuan Li has completed her PhD from the Ministry of Education Key Laboratory of Laser Life Science of South China Normal University. She is a Lecturer of Dalian Medical University. She has published more than 10 papers in reputed journals and has been serving as an Editorial Board Member of Edorium Journal of Emergency Medicine. She has been supported by National Natural Science Foundation of China, and the Educational Commission of Liaoning Province of China.

Abstract:

Ubiquitin Carboxy-Terminal Hydrolase-L1 (UCH-L1) has been established as a reliable and potential biomarker of neuronal damage. There is not much information about the effects of White Matter Lesions (WMLs) on serum UCH-L1 levels in white matter disease patients. This study was aimed to assess whether serum UCH-L1 levels are a reliable marker of brain damage in patients with WMLs. Serum levels of UCH-L1 were assessed by sandwich Enzyme-Linked Immunosorbent Assay (ELISA) in 74 patients with type 2 diabetes mellitus, depression, or vascular disease. MRI was performed by a neuro-radiologist blinded to clinical data. Of these 74 patient cases, 26 showed periventricular WMLs, 22 showed subcortical WMLs, and 26 displayed no well-defined WMLs (controls). Serum UCH-L1 levels were significantly different between the two groups (p<0.05). Further sub-group analysis proved that serum UCH-L1 levels in participants with sub-cortical WMLs were significantly increased when compared with controls (p<0.001), but there was no significant differences between controls and patients with periventricular WMLs (p>0.05). These findings suggest that serum UCH-L1 levels may serve as a novel biomarker for neuronal damage from WMLs, especially sub-cortical WMLs.

Biography:

Eman A Hammad was awarded her PhD from the University of East Anglia, UK in 2013. She currently teaches and researches in Clinical Pharmacy Practice and Health Economics. She finished her Undergraduate degree in Pharmacy and Master degree in Clinical Pharmacy form the University of Jordan in 2007 and 2010. She has a number of published papers evaluating health care services and pursue to assess the cost effectiveness and cost implications of pharmacy led interventions at hospital settings as well as in community settings. An intervention of most research interest to her has been pharmacy led medicine reconciliation.

Abstract:

Objective: To review the evidence for the effects and costs of complete pharmacy-led MR in hospital settings.

Data Source: Electronic databases were reviewed up to the 15th March 2015 including EMBASE & MEDLINE Ovid, CINAHL and the Cochrane library.

Study Selection & Data Extraction: Studies evaluating complete, pharmacy-led MR in hospital were included. Five steps were associated with the delivery of complete MR: Develop a list of current medicines; develop a list of medicines to be prescribed; compare the medicines on the two lists; make clinical decisions based on the comparison and communicate the new list to the next care provider and to the patient. Articles were screened and extracted independently by two authors.

Data Synthesis: Studies were divided into those in which: MR was the primary element of the intervention and labelled as “primarily MR” studies, and those where MR was performed in addition to non-MR care interventions and labelled as “supplemented MR” studies. Quality assessment of studies was performed by independent reviewers using a pre-defined tool. The literature search identified 4,065 citations of which 13 met the inclusion criteria. There was a scarcity of rigorously designed studies regarding the effects and costs of pharmacy-led hospital based complete MR.

Conclusion: No evidence to support the cost-effectiveness of pharmacy-led MR intervention was identified. The nature of reporting prohibited isolation of the effect and costs of pharmacy-led MR in the absence of other non-MR healthcare interventions.

Biography:

Hanaa Alghonaimy is working as a Faculty of Pharmacy Ain Shams University, Egypt. She completed her education in Ain Shams University. Her work experience on Export Regulatory Affairs Associate Manager atEgyphar

Abstract:

Unfractionated Heparin (UFH) has been conventionally used during Coronary Angiography (CAG). However, no data is available for the dosage required. Vascular complications are still frequent in special group of patients. The objective of this study was to determine the incidence of bleeding, vascular, and ischemic complications using three different heparin regimens after successful coronary angiography. This study enrolled 105 patients divided into three groups: Group 1: (n=35 patients) receiving a dose of 5000 IU (systemic heparinization), Group 2: (n=35 patients) receiving a dose of 5000 IU of heparin on the flush saline and Group 3: (n=35 patients) control group will receive flush saline, i.e., normal saline flush. All patients included in the study will be subjected to full history taking, complete general and local examination of the heart and blood vessels, 12 leads resting ECG, Routine laboratory investigations including fasting blood sugar, liver and kidney function tests, complete blood picture, lipid profile and coagulation profile. Descriptive statistics was done including mean, standard deviation and percentage. Comparison between groups was done using one way analysis of variance and comparison between the parametric variables was done using chi-square test. Results of the current study showed that there was no significant difference between the three groups regarding the number of diseased vessels or the incidence of slow coronary flow or incidence of normal coronary arteries (p>0.05). The clotting time and PTT were not significantly different in the three groups before coronary angiography (p>0.05). After coronary angiography, clotting time and PTT were significantly higher among group I and II than that of group III (p<0.05). Comparison between before and after coronary angiography in group I and II, the results showed that the clotting time and PTT increased significantly after the procedure (p<0.05) while, in group III there were no significant difference between before and after the procedure (p>0.05). The sheath removal duration was significantly higher among group I and group II than that of group III (p<0.05). There were no major complications recorded in any of the patients in the three groups. Routine elective coronary angiography may be performed without the use of UFH was found to be safe. However, further detail study is recommended.

Biography:

Zayed Nama Alsulami is a paediatric clinical pharmacologist working for Alkharj Military Hospital in Alkharj City, Saudi Arabia. Zayed has completed his PhD from University of Nottingham in 2013. His main role is to conduct research into paediatric drug therapy and medication errors including the medication errors in the Middle East countries, Nurses adherence to double check process and medication administration errors in children.

Abstract:

Background: Children are more susceptible to medication errors than adults. Medication administration process is the last stage in the medication treatment process and most of the errors detected in this stage. Little research has been undertaken about medication errors in children in the Middle East countries.

Aim: To evaluate how the paediatric nurses adhere to the medication administration policy and also to identify any medication preparation and administration errors or any contributory factors that may affects the nurses’ practice during their medication administration process.

Method: This was a prospective direct observational study of medication administration process, from when the nurses preparing patient medication until administration in the patient room in the paediatric ward (May to August 2014). Also, the observers were documented any medication administration errors occurred during the study period. Main outcomes were adherence rate of each step of preparation and administration process, number of errors and associated risk factors. All data collected was anonymous and was recorded on a data collection form which was designed specifically for this purpose.

Results: Twelve paediatric nurses serving 90 paediatric patients were observed. 456 drug administered doses were evaluated. Adherence rate was variable in 7 steps out of 16 steps. Patient allergy information, dose calculation, drug expiry date were the steps in medication administration with lowest adherence rates. 63 medication preparation and administration errors were identified with error rate 13.8% of medication administrations. No potentially life-threating errors were witnessed. Few logistic and administrative factors were reported.

Conclusion: Medication administration policy and procedure need an urgent revision. Nurses’ knowledge and skills regarding to the medication administration process should be improved.

Biography:

Romany Helmy Thabet is a PhD degree holder and an Assistant Professor of Pharmacology, Faculty of Medicine, Northern Borders University, Saudi Arabia. His latest published textbook is “Fundamentals of Medical Pharmacology”. He has several internationally published papers.

Abstract:

Aim of the study: Pentylene tetrazol (PTZ) is a commonly employed chemo-convulsant, used for screening drugs for anticonvulsant activity. The present study is aimed at investigating the differential effects of adenosine and the adenosine A1 agonist, N6- Cyclopentyladenosine (CPA) against seizures induced by pentylenetetrazol (PTZ). Methods: This study was carried out by investigating the effect of pretreatment of rats with adenosine and CPA on pentylene tetrazoleinduced seizures. Acute toxicity of PTZ in rats was studied by determination of median convulsive dose (CD50) of PTZ alone and after pretreatment of rats with each of adenosine and CPA. Results: Adenosine, when administered to rats intra-peritoneally in a dose of 1000 mg/kg 5 minutes prior to acute challenge with PTZ in a dose of 60 mg/kg, produced significant protection against PTZ- induced seizures. CPA, when administered intraperitoneally to rats in a dose of 10 mg/kg 60 minutes prior to acute challenge with PTZ in a dose of 60 mg/kg, also showed significant protection against PTZ induced seizures. Conclusion: CPA significantly protected against seizures after acute PTZ administration and this indicates that the anticonvulsant effect of PTZ is via stimulation of A1 receptors.

Biography:

Dr Nawaf Alrawilli is working as a Faculty of medicine-Northern Borders University, Arar, Saudi Arabia. And his research interest is on General Clinical Pharmacology

Abstract:

Background and aim of the work: Rheumatoid arthritis (RA) is an autoimmune disorder of unknown cause. It is a highly inflammatory polyarthritis disease often leading to joint destruction, deformity and loss of function. There is conflicting data about the effect of PDEIs on pathogenesis of RA. This work aims at investigation of the effect of rolipram as representative of PDEIs on signs, symptoms, histopathology and cytokines of adjuvant-induced arthritis (AIA), a model of RA in rats that exhibit several pathological changes similar to those occurring in RA. Methods: In the present study, we used rat model of adjuvant-induced arthrits (AIA), a model of RA in rats that exhibit several pathological changes similar to those occurring in RA in human, by subplantar administration of Freund’s adjuvant into hind paws of rats. Arthritis index, volume of hind paws edema, body weight, rectal temperature and pain threshold to pressure on hind paws, were measured daily from day 0 until day 30 after adjuvant inoculation. At the end of the study, the animals were sacrificed and the blood was collected for measurement of serum levels of TNF-alpha and IL-10. To assess the secondary immune reaction, specimens of left ankle joint tissues were also examined for histopathology. Results: Rolipram therapy, either prophylactic or therapeutic, significantly leads to marked suppression of adjuvant arthritis in rats depending on the dose administered. The therapeutic efficacy of rolipram was evidenced by decreased arthritic scores, and hind paw volumes of arthritic rats. Hyperalgesia of adjuvant arthritic rats was significantly reduced in rolipram-treated animals compared to non-treated group. Prophylactic rolipram protocols have dramatic protective effect as evidenced by inhibition of inflammatory cellular infiltrate in synovium of arthritic rats, pannus formation and alleviation of the destruction of the articular cartilage. The present study demonstrated that prophylactic or therapeutic administration of rolipram did not alter significantly the serum level of TNF-α. Regarding IL-10, our study demonstrated a significantly augmenting effect of treating adjuvant arthritic rats with rolipram, from day 16 to day 25 after disease induction in a dose of 3 mg/kg/d given orally. Interestingly, the present work demonstrated that joint inflammation was significantly attenuated by DMSO treatment as evidenced by lower clinical scores and reduced paw swelling. Conclusion: The results presented in this study shows that rolipram, a PDE 4 inhibitor displayed an anti-inflammatory, anti-arthritic and anti-hyperalgesic actions in adjuvant arthritic rats in a dose-dependant manner. In conclusion, these findings suggest that rolipram may have therapeutic value for various autoimmune diseases such as rheumatoid arthritis.

Biography:

Alexander E. Berezin received the MD degree from State Medical University, Zaporozhye, Ukraine, in 1992 (Number of License is 827456 / 6637 dated 25 JUN 1992). PhD degree in field of Heart Failure was earned in State Medical University, Zaporozhye, Ukraine in 1994. The primary qualification is internal medicine; the secondary qualifications are cardiology, rheumatology, and ultrasound exam. He is currently Professor of Medicine, Consultant of Cardiology Unit of Internal Medicine Department at State Medical University, Zaporozhye, Ukraine

Abstract:

Background: Acutely decompensated chronic heart failure (ADHF) is considered a life-threatening event. Despite contemporary treatment strategies of ADHF, frequent recurrent hospitalizations due to other cardiovascular reasons after discharge of patients from the hospital are occurred. The objective of the study was to examine prognostic value of circulating endothelial-derived apoptotic microparticles (EMPs) to endothelial origin mononuclear progenitor cells (MPCs) ratio for post-discharged patients with clinical stabilization after ischemic ADHF. Methods: We have been consecutively enrolled 136 patients (62 male) with CAD admitted with a primary diagnosis of ADHF. All the patients have given their written informed consent for participation in the study. At baseline all enrolled patients were hemodynamically stable and they had NYHA III/IV classes of ischemic CHF. Observation period started at discharge from the hospital and was up to 3 years. Flowcytometry analysis for quantifying the number of EMPs and angiogenic MPCs was used. Results: Calculated EMPs to MPCs ratios in survived and died patient cohort were 8.4 (95% CI = 7.6 – 9.2) and 78.9 (95% CI = 53.0 – 116.6) respectively (P=0.001). MPCs, EMPs, NYHA class, NT-proBNP and increased NT-proBNP > 30% within 24-48 hours of admission period remained statistically significant for all-cause mortality, CHF-related death, and CHF-related rehospitalisation, whereas LVEF and hs-CRP for all variables did not. We found that the addition of EPMs to MPCs ratio to the ABC model (NT-pro-BNP, increased NT-pro-BNP > 30%) improved the relative IDI by 19.6% for all-cause mortality, by 21.7% for CHF-related death, and by 19.5% for CHF-related rehospitalisation. Conclusion: We demonstrated that EMPs to MPCs ratio is considered more tremendous indicator of an imbalance between angiogenic and apoptotic responses with possible relation to cardiovascular outcomes in post-discharged patients with clinical stabilization after ischemic ADHF.

Biography:

Kjell Erling Bjørnæs has completed his Master of Science in the field of Osteopathy at The University of Greenwich, UK and followed a PhD program at Center for Epidemiology and Research Methodology, University of Life Sciences Oslo, Norway He is international lecturer in Osteopathy, and researcher at Nordic Osteopathic Research Institute. The field of research is: Gastro Esophageal Reflux Disease (GERD), totally 4 studies. He is the manager at Osteopathic Clinic – Norway.

Abstract:

Aim: To compare the effect of Osteopathic Manipulation Therapy (OMT) on Gastroesophageal reflux disease (GERD) against placebo. Material: The material consists of 58 patients suffering from GERD symptoms of 10.7 years. Twenty-six males and 18 females were allocated to OMT and eight males and six females to placebo. Methods: A randomized, double observer blinded multicenter trial with stratified parallel group design was performed. Patients were allocated (3:1) to OMT or placebo by block randomization. OMT includes traction of cardia, mobilization of diaphragm and thoracic spine and posture correction once per week. The controls treated with non-active laser pen on the epigastric area. The degree and duration of GERD symptoms, provocation factors and use of anti-reflux medication was recorded by the patients. Results: All the GERD symptoms was significantly reduced (p<0.01) one week after the last treatment in the OMT group compared to none among the controls. The reductions were significantly in favor of OMT (p< 0.01). “Acid taste in mouth” and “Heart burn “explains 81% of the variation in reduced sum degree of symptoms. The median time of pain release was reduced from 1.5 to 0.5 hours in the OMT, but unchanged in the control group (p<0.01). Four patients stopped using proton pump inhibitors, one stopped the H2 treatment and four the antacid medication in OMT. The use of anti-reflux medication was unchanged in the control group. Conclusion: OMT have a significant effect on the GERD symptoms and might be an alternative in treatment of reflux esophagitis.

Biography:

Julia Greenawalt is working as a Asst. Professor at Indiana University of Pennsylvania. She completed her education in University of Pittsburgh. Her work experience on Clinical Research, Public Health

Abstract:

Teaching documentation skills and concepts to the emerging professional is a new challenge for nurse educators as the infusion of meaningful use is implemented within nursing's affiliating agencies. Discipline mandates and accreditation requirements expect the emerging professional to be current in technology and communication as one prepares to care for patients in contemporary times. This presentation will share how meaningful use has been incorporated into one obstetrical course in a baccalaureate nursing program. This is necessary for other disciplines to understand how and where meaningful use impacts their operations. In addition, we will discuss some of the current challenges as we go forward pulling from real life experiences of one nurse faculty member’s exposure to the infusion of meaningful use into course and practicum, events when meaningful use goes inactive and operations remain ongoing, and the actions taken to mitigate future safety and sentinel events. This experience illuminates the need for inter-professional on-going collaborative efforts to enhance patient safety from an informatics perspective. However, the best method of instruction for teaching learning to undergraduate nursing students as relates to electronic documentation remains unclear at this time. Current inquiry and future research into evidence-based practice are needed as preparation gears toward workforce ready graduates who will be skilled and adept at documentation using current technologies. Teaching skills for information systems, particularly the electronic health record, requires identification of challenges and obstacles, which can be surmounted if academe and corporate culture work in tandem.

Biography:

Humpher Faria de Souza has 31 years old. He is student and is completing the sixth period of the Pharmacy Course at the Faculty Pythagoras of Ipatinga, Minas Gerais, Brazil. He intended as a researcher and do master's degree in Clinical Pharmacy.

Abstract:

Metabolic syndrome (MS) results from a number of risk factors for cardiovascular disease, and the main, central obesity, hypertension and abnormalities in glucose and lipid metabolism. As obesity in the world has taken pride of place, we can conclude that adipose tissue is a component of the pathogenesis of MS, which demonstrates the importance of body fat distribution, especially visceral. As a risk factor fastest growing in prevalence and severity, and a negative aesthetic issue, obesity should be today a priority for public health. Due to its complexity, including clinical, epidemiological and psychosocial, requiring a comprehensive and multidisciplinary approach. Based on survey data, there are doubts about the existence of the association of obesity and metabolic syndrome. Experimental studies in humans and also show obesity is a risk factor capable of causing an increase in blood pressure. There is evidence on the involvement of insulin resistance and hyperinsulinemia, although not yet available long-term prospective studies that can provide one. Insulin resistance is associated particularly with abdominal distribution of body fat. It is believed that the high cardiovascular risk attributed to intra-abdominal adiposity is related to the development of metabolic syndrome, which is attended obesity and hypertension among others. This work had as main objective to define and describe the metabolic syndrome, as well as its causal factors, consequences and treatment. The methodology was systematic literature review from the databases indexed in LILACS, BIREME, Medline and others. Conclusion: The metabolic syndrome may therefore be defined as a chronic degenerative metabolic disease characterized by association between insulin resistance, hypertension, dyslipidemia, diabetes mellitus type 2 (DM2), and other metabolic abnormalities. And, being a metabolic syndrome, it is important that the pharmacist know this disease and the health damages caused by it, so it can be diagnosed and treated correctly associating drugs, diet and physical activity provide a better physiological condition, health and quality of life for individuals.

Biography:

Stig Larsen has completed his DSc in Clinical Research Methodology at Ullevål Hospital, Oslo University, Norway. He is Professor at the Norwegian University of Life Science and has published more than 300 papers in international medicine and clinical research methodological journals.

Abstract:

BP-C1 is currently used in treating metastatic breast cancer patients, controlling tumor growth, improves quality of life with a few mild side-effects. Methods: The material consists of laboratory results from 47 patients in two controlled clinical trials with daily IM injections of BP-C1 for 32 days. Study I was performed as an open non-randomized, Phase I dose-response study with a 3-level between-patient Response-Surface-Pathway design. The second study as a randomized double-blinded and placebo controlled multicenter study with stratified semi-cross-over design. Results: Hemoglobin and hematocrit increased significantly (p<0.01) during BP-C1 treatment, while red blood cell count increased but not significantly, the most pronounced increase was in anemic patients (p≤0.01). White blood cell count and neutrophils increased significantly (p= 0.01) in the total material. These variables (p<0.01), eosinophils (p=0.05) and monocytes (p<0.01) increased significantly and markedly in patients with lowest baseline levels. Additionally, low levels of thrombocytes significantly increased. No changes in liver parameters, amylase, glucose, creatinine, or albumin were detected except for albumin in the subgroup with low baseline, where levels increased significantly (p=0.04). An increase in K+, Ca2+ and PO4 3- was most pronounced in patients with low baseline levels (p≤0.02). A similar pattern detected for Mg2+, PT, KFNT and CRP increased significantly (p≤0.05) in the groups with the lowest values. Conclusion: Our findings support the safety profile of BP-C1 and did not induce to anemia, infection, bleeding, hepatic insufficiency or electrolyte imbalances, but corrugated abnormalities.

Biography:

Gunnard has over 30 years of experience with industrial yeasts and supplies technical support to the Lesaffre Group’s US operations and Lesaffre Human Care. He has a Ph.D. in microbial physiology from Oregon State University. He has experience in yeast mutational genetics and has been actively involved in strain development of industrial yeast for multiple applications. Recently, he has been involved in the use of fortified yeasts for human nutrition and probiotic microorganisms for the promotion of human well being.

Abstract:

With a worldwide prevalence of 5-20%, Irritable Bowel Syndrome (IBS) is associated with high direct and indirect health costs. Its pathogenesis remains unclear, the efficacy of available treatments is modest and short-term, and their tolerance is poor. Saccharomyces cerevisiae CNCM I-3856, proprietary to Lesaffre, has been evaluated in a randomized, double blind, placebo-controlled clinical trial in 179 adults with IBS according to Rome III criteria. Patients received either 500 mg of CNCM I-3856 daily or a placebo for 8 weeks followed by a 3-week washout period. After a 2-week run-in period, cardinal symptoms (abdominal pain/discomfort, bloating/distension, flatulence, bowel movement difficulty) and changes in stool frequency and consistency were recorded daily and assessed each week. In the last 4 weeks of treatment, the proportion of responders, defined by an improvement of abdominal pain/discomfort, was significantly higher (p = 0.04) in the CNCM I-3856 group than the placebo group (63% vs. 47%). These clinical results were strengthened by multiple-choice questionnaires evaluating consumer satisfaction of Ibsium®, a CNCM I-3856 food supplement. Upon physician recommendation, 1161 patients consumed one Ibsium® capsule per day for a 1 to 3-month period. 96% reported a significant improvement of their symptoms (mainly abdominal pain (64%) and bloating (70%)), and, for 77% of subjects, this improvement was obtained within the first 5 to 15 days of consumption. 99% of consumers reported that they tolerated the product well. Ibsium® (Saccharomyces cerevisiae CNCM I-3856) is a natural, well-tolerated solution for the long-term management of abdominal discomfort; offering relief without side effects or habituation.

Biography:

Bård Dalhøi D.O. (Dr. Osteopathic Manual Medicine) ongoing PhD studies, and co-founder of Heads AS, Norway. Vice President R&D at Heads AS. Company has ongoing R&D for new certified medical technology. Products sold in research and in clinical medical professions like ENT, Neurology, Ophthalmology, Optometry and Emergency Room. The company has ongoing collaboration with EU medical universities, USA Optometry Universities and Vision Research Foundation/Eye Hospital in India.

Abstract:

A new prototyped eye tracking technology with functional oculomotor disorders and reading disabilities is introduced. The aim is to investigate intra and inter reliability of oculomotor functions expressed in eye saccades and smooth pursuits. Material: The reference population consists of children and adults of both genders between five to 70 years of age with normal or dysfunctional conditions in eye movements, classified by the optometrist. The study sample consisted of six controls and 12 oculomotor disabled subjects related to age and dysfunction. Methods: The dysfunction was classified as “normal”, “mild”, “moderate to severe”. The study was performed as a randomized observer blinded trial with stratified, nested Latin squared design. The sequence of investigation was allocated by a 3x3 Orthogonal Latin square. Results: Kappa analysis was performed and intra agreement for both the optometrists and the eye tracker were classified as “Very good”. Additionally, the agreement between the eye tracker and each of the two optometrists were found classified as “Good”. Conclusion: the eye tracker seem to be a reliable and valid method to measure oculomotor functions in eye saccades and smooth pursuits

Biography:

Julia Greenawalt is working as a Asst. Professor at Indiana University of Pennsylvania. She completed her education in University of Pittsburgh. Her work experience on Clinical Research, Public Health

Abstract:

Teaching documentation skills and concepts to the emerging professional is a new challenge for nurse educators as the infusion of meaningful use is implemented within nursing's affiliating agencies. Discipline mandates and accreditation requirements expect the emerging professional to be current in technology and communication as one prepares to care for patients in contemporary times. This presentation will share how meaningful use has been incorporated into one obstetrical course in a baccalaureate nursing program. This is necessary for other disciplines to understand how and where meaningful use impacts their operations. In addition, we will discuss some of the current challenges as we go forward pulling from real life experiences of one nurse faculty member’s exposure to the infusion of meaningful use into course and practicum, events when meaningful use goes inactive and operations remain ongoing, and the actions taken to mitigate future safety and sentinel events. This experience illuminates the need for inter-professional on-going collaborative efforts to enhance patient safety from an informatics perspective. However, the best method of instruction for teaching learning to undergraduate nursing students as relates to electronic documentation remains unclear at this time. Current inquiry and future research into evidence-based practice are needed as preparation gears toward workforce ready graduates who will be skilled and adept at documentation using current technologies. Teaching skills for information systems, particularly the electronic health record, requires identification of challenges and obstacles, which can be surmounted if academe and corporate culture work in tandem.

Biography:

Espen Glomsrød has completed his MSc in 2013 from University of Bergen, Norway. From 2002-2013 he worked as a teacher of osteopathy in Nordisk Akademi for Ostopati and Norges Helsehøyskole Campus Christiania, Oslo, Norway. He works as an Osteopath DO (eur.) MSc in a private clinic in Halden, Norway.

Abstract:

Background: Dose- response studies are needed for pharmaceuticals, but have not been commonly performed in the field of manual therapy. Objective: The aim of this study was to determine the combination of treatment numbers and intervals needed to obtain the optimal effect of osteopathic treatment for patients with chronic non-specific low back pain. Design: The study was performed as an open, randomized, single -centre trial with a 22 factorial design. Methods: The patients were allocated equally to four groups by block randomization. The first group was given two treatments at an interval of 14 days, the second group was given two treatments at an interval of seven days, the third group received four treatments with intervals of 14 days, and the fourth group received four treatments with intervals of seven days. Oswestry Disability Index (ODI) and the Numeric Rating Scale (NRS) were recorded at baseline and two weeks post treatment. Participants: Eight women and four men with chronic non-specific low back pain were included. Results: The two treatments with an interval of 14 days resulted in an ODI reduction of only 1.3 (95% CI: -21 – 24.1). The largest reduction in ODI was detected in the four treatments with the seven days intervals. The mean reduction in this group was found to be 19.3 (95% CI: -14.4 – 53.1). An interaction between the number of treatments and the treatment interval was observed. Conclusion: The effect increased with increases in the numbers of treatment and reductions in the treatment interval. The program with four treatments and intervals of seven days was found to be optimal among the four examined regimens.